Brain specimens are obtained under protocols approved by the CNS IRB (NCT03092687), with the permission of the next-of-kin (NOK) through the Offices of the Chief Medical Examiners (MEOs) in the District of Columbia, Northern Virginia and Central Virginia. All specimens were characterized neuropathologically, clinically and toxicologically. A clinical diagnosis was obtained through family interviews and review of medical records by two psychiatrists based on DSM-IV criteria. Non-psychiatric controls were defined as having no history of a psychiatric condition or substance use disorder and negative toxicology measures.
