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Chunk #23 — Results — Overlap of Enriched Pathways Between CNV and SNP Data

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Investigating the contribution of common genetic variants to the risk and pathogenesis of ADHD.
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We included 727 ADHD case subjects and 1,047 comparison subjects in the CNV analysis. We observed a significantly (p=0.002) higher rate of large (>500 kb), rare CNVs in case subjects (N=85, 21 deletions, 64 duplications) than in comparison subjects (N=78, 13 deletions, 65 duplications). In the subset of the 727 ADHD case subjects (N=409) that had not been included in the previous report (5), the rate of large, rare CNVs was also significantly greater than in the comparison subjects (rate=0.112, compared with 0.075; p=0.02). More information is provided in Table S5 in the online data supplement.