Chunk #16 — Materials and methods — Polygenic risk score phenome-wide and lab-wide association scans in BioVU

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Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry.

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For each of the unrelated genotyped individuals of European ancestry from BioVU, we computed polygenic risk scores (PRS) for POU using the PRS-CS “auto” version [34]. Genotyping and quality control for this cohort have been extensively described [35, 36].