To explore whether pleiotropic effects for POU are associated with an array of other medical ailments and biomarkers, we performed phenome-wide and lab-wide association scans (PheWAS, LabWAS), respectively. These analyses were conducted using data from the Vanderbilt University Medical Center (VUMC). The project was approved by the VUMC Institutional Review Board (IRB #160302, #172020, #190418). VUMC is an integrated health system with individual-level health data from electronic health records (EHR) for about 3.2 million patients. The VUMC biobank contains clinical data from EHR as well as biomarkers obtained from laboratory assessments. A portion of the individuals from VUMC also have accompanying array genotyping data. This cohort, with over 66,903 patients, is called BioVU [34, 35].
