Chunk #1 — Methods and Materials — Subject Recruitment — Initial Discovery Sample: Center for Education and Drug Abuse Research and Substance Abuse and the Dopamine System
The Center for Education and Drug Abuse Research (CEDAR) sample was ascertained as part of a large longitudinal study of substance abuse risk. Nuclear pedigrees were ascertained through the father, who did (case; DUD+) or did not (control subject; DUD−) have a substance use disorder (abuse or dependence) related to an illicit drug (an illegal substance or nonmedical use of a prescribed psychoactive drug). A DSM-III-R diagnosis was used because DSM-IV was introduced after this study started. Control subjects had no Axis I or II psychiatric disorder. Both cases and control subjects were required to have no history of psychosis, a Wechsler Adult Intelligence Scale-Revised full-scale IQ in the normal range, and good health status and had a 10-to 12-year old child at the time of ascertainment and first assessment.
