We report the top associated SNP in each ancestry group, as well as the top associated SNP in the combined sample (Table 1; Figure S2). As discussed in the Subjects and Methods section, we utilized different methods to control for genetic background heterogeneity and admixture, but generally obtained similar results for all the methods. As shown in Table 1, the most significant associations were different between the EA and AA subjects. For the EA sample, the most significantly associated SNP was rs1825828 at 3q11.2, p = 7.0 × 10-7. However, upon inspection of the genotype intensity plot (see Figure S2), rs1825828 appeared to be poorly genotyped. The second-best association was rs5907577 in an intergenic region at Xq27.1, p =1.6 × 10-6. For the AA sample, the most significantly associated SNP was rs2111504 in DPY19L3 at 19q13.11, p = 1.5 × 10-6. In addition, we looked for regions where there were multiple SNPs with low p-values (p < 1 × 10-4) with close physical proximity to one another (i.e., within 100kb). We report two regions that contain 5 SNPs that meet
