Bayesian posterior probabilities of relevance of 5-HTTLPR for the multivariate phenotype.RLE was grouped into three categories: low = 0–1, medium = 2, high = 3 or more number of recent negative life events (in the past year). CHA (childhood adversity) was divided into two categories (based on the original three): low = 0–3, medium or high = 4 or more scores. Multivariate phenotype (more accurately describes depression related psychiatric state than one phenotype measure alone) encompasses lifetime depression, BSI depression score and BSI anxiety score. Results are displayed according to CHA and age, in groups differentially exposed to RLE. 3A and 3B. Results demonstrate moderate Bayesian probability of relevance of 5-HTTLPR in both age groups and CHA groups in those who had 3 or more RLE. 3C. In the younger age group (≤30) 5-HTTLPR was strongly relevant in those who had medium or high CHA and even moderate number of RLE. 3D. In the older age group (>30) 5-HTTLPR was strongly relevant in those who had 3 or more RLE, irrespective of CHA.
