A multi-ancestry fixed-effects meta-analysis of EA, AA, and LAT GWAS (150,793 cases, 1,130,197 controls) identified 85 GWS loci. Compared to the EA meta-analysis, 10 loci lost GWS, while 14 previously suggestive loci (P < 5 × 10−7) became GWS (Fig. 2). In total, the present study identified 95 unique GWS PTSD loci between the EA and multi-ancestry meta-analyses (Table 1). Due to the complex local ancestry structure in AA and LAT individuals, which complicates LD modeling, we focused subsequent fine-mapping analyses (Fig. 1b) on data from the EA GWAS.
