At TFAP2B, CHARGE analyses revealed directionally-consistent association with WC (rs987237, N = 31,372, P = 3.6×10−4) resulting in a combined P-value of 1.9×10−11 (N = 118,691). At MSRA, genotypes for rs7826222 could only be imputed in a subset (N = 8,097) of CHARGE samples (this reflects SNP nomenclature issues rather than data quality – see Text S1). Nonetheless, the effect in CHARGE was directionally consistent (P = 0.28), and in the overall results (N = 80,210) for this SNP, the evidence for association with WC was improved (P = 8.9×10−9) (Table 1).
