In contrast, rs6429082 in TBCE showed no evidence of association with WC in the full CHARGE data set (N = 31,373, P = 0.12). Since analysis of the combined data set no longer reached genome-wide significance (P = 2.9×10−7), further studies will be required to establish the status of this signal. For the TFAP2B and MRSA loci, there was no evidence of heterogeneity of effect size across the various sample sets, and no evidence that the inclusion of diabetes or coronary artery disease case samples had any impact on the associations (Table S2).
