The overall most differentiating absolute risks for developing a comorbid disorder were seen for males in the top aggregate PRS decile, reaching risks of 35% and 25% for developing SUD and schizophrenia, respectively, in contrast to the lowest decile case groups (both sexes) with risks of 4% (SUD) and 8% (schizophrenia) and the background population without a depression diagnosis with risks of 2% (SUD) and 1% (schizophrenia) for the middle deciles.
