Performing sex-specific analyses revealed substantial differences in absolute risks between the sexes (Supplementary Figures S20-S23), most considerably for developing SUD and schizophrenia. For SUD, male risks reached 35%, 15% and 6% for PRS decile 10, middle and 1, respectively, while female risks were 15%, 7% and 3%. For schizophrenia, the risks for males were 25%, 13% and 13% compared to 9%, 8% and 8% for females.
