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Chunk #19 — Materials and Methods — Genome-wide complex trait analysis (GCTA)

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A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
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The GCTA program as described by Yang and colleagues (Yang et al. 2011) was used to estimate the proportion of phenotypic variance for maxdrinks explained by the genome-wide SNPs genotyped on the Illumina 1M chip in the SAGE dataset. This program fits a linear model to the phenotype data and uses a restricted maximum likelihood to estimate the variance explained by the SNPs.