No SNP, either genotyped or imputed, passed our pre-specified threshold of genome-wide significance of p<5×10−8 for association with maxdrinks (Supplementary figure 2). A total of 479 SNPs showed association at p < 1 × 10−4 (Supplementary table 1), which is higher than the number of SNPs (406) (p = 0.015) expected by chance. The strongest association with maxdrinks was detected with an imputed SNP, rs9523562 (beta = −0.13, p=2.1 × 10−6), on chromosome 13q31.1. Several genotyped and imputed SNPs that are highly correlated with rs9523562 (R2=0.8, D′=0.95) also showed association with maxdrinks (5.0 × 10−5 ≤ p ≤ 2.1 × 10−6) (Supplementary table 1). An intronic SNP rs2283970 in CACNG2 (calcium channel, voltage-dependent, gamma subunit 2) also showed suggestive association (beta = −0.13, p=3.9 × 10−6).
