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Chunk #7 — Given the Evident Challenges, How Do We Look for GXE interactions

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Consilient research approaches in studying gene x environment interactions in alcohol research.
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In attempting to judge consilience, the ecological meaning of an environment and the effect it has on underlying neurobiology is more critical than how phenotypically similar it appears to be to its human counterpart. Extraordinary claims require extraordinary evidence and so if one wants to claim that there is an animal model of a specific behavioral process (e.g., guilt) associated with a specific environment (e.g., strong social sanctions), then one would want to see this demonstrated across multiple behavioral paradigms with reference to common neural circuitry (Institute of Medicine, 2006).