humans and nonhuman animals (Etten, Higgins, & Bickel, 1995). Finally other kinds of psychosocial variables such as parental neglect can be modeled although what is considered to be neglect in humans (e.g., lack of nurturance, inadequate attention to basic physical needs, or supervision) might look phenotypically very different in rodents (e.g., lack of maternal pup retrieval to the nest and licking).