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Chunk #62 — METHODS — Genetic overlap with other phenotypes.

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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.
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univariate step were used to run a bivariate model in a pairwise fashion (i.e. ADHD vs. each of the other traits), which produced estimates of SNPs with a specific effect on the first or on the second trait, and SNPs with a non-zero effect on both traits (for details on the method see also ref. 18 and Supplementary Note). The models were evaluated by the Akaike Information Criterion52 (AIC) and illustrated with modeled versus observed conditional quantile-quantile (Q-Q) plots (Supplementary Fig. 11). The AIC values can be found in Supplementary Table 19.