Chunk #63 — METHODS — Polygenic score (PGS) analysis of cognitive measures in PNC.

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Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.

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PGS analysis was performed on 4,973 individuals of European ancestry from the Philadelphia Neurodevelopmental Cohort (PNC), ages 8–21. Information about imputation and QC of the PNC data can be found in the Supplementary Note.