These analyses evaluated whether a long-term prospective study of the development of AUDs and/or SUDs in men corroborated several findings from prior cross-sectional and retrospective studies. The rates of alcohol-related conditions in the current sample reflect the fact that half of the men had an alcoholic parent. Over the 30 years, 41% of these probands developed an AUD, compared to an estimated 12 month or lifetime risk of 15% to 20% in the general population (e.g., Chou et al., 2012; Kessler et al., 2005; Teeson et al., 2010). However, considering the fact that these high functioning probands had not been selected for a FH of SUDs, the 21% rate of drug-related conditions found in these analyses, compared to general population lifetime estimates of about 10% (Kessler et al., 2005; Wagner and Anthony, 2003), might have been less expected. As predicted by Hypothesis 1 and several reports in the literature (e.g., Stinson et al., 2005; Teeson et al., 2010), the presence of either an AUD or a SUD was associated with an increased rate of the other diagnosis. This increase for
