To assess the proportion of variance in liability for broad ASB explained by all measured SNPs, we computed the SNP-based heritability (h2SNP) through LD score regression (LDSC) [30]. The h2SNP was estimated to be 3.4% (s.e. = 1.2%) in the quantitative BroadABC data, 24.8% (s.e. = 3.1%) in the Psychiatric Genetics Consortium/iPSYCH case-control data (with a prevalence estimate of 2% in the population) and 7.7% (s.e. = 1.1%) in the combined meta-analysis.
