The GPC has created a system that allows outside investigators, with appropriate review and approval, to collaborate in, propose, and co-lead studies involving GPC participants. Our goal in establishing the GPC has been to establish a resource for the field. To this end, we have sought to collaborate with experts in various fields, leading to several new collaborative research projects (Table II). We have established a GPC Protocol Review Committee with selected site principal investigators (PIs), selected collaborating PIs, and an NIMH representative that reviews and recommends approval of projects involving GPC participants that are proposed by outside investigators.