Chunk #35 — Statistical Methodology for the Analysis of Association Trajectories — Identification of significant SNPs — Significant SNPs identified by concentration of effect sizes
To determine whether large effect sizes were distributed randomly across SNPs for sets of correlated phenotypes or concentrated in relatively few SNPs, the distribution of observed concentrations were tested against the hypothesis that there were no SNP-specific concentrations by a permutation test. The emphasis on SNPs is achieved by aggregating values across locations on the scalp, since phenotypic values are highly correlated over scalp locations.
