The Genetics of Antisocial Drug Dependence (GADD) sample is a multisite research project that began in 2000 to focus on antisocial drug dependence. Probands in Denver and San Diego were identified via residential or outpatient treatment programs, involvement with the criminal justice system, or special schools with the presumption of having a substance use disorder or conduct disorder. A sibling and one or both biological parents who agreed to participate were also tested. At the time of recruitment probands were 14-19 years old, had an IQ of > 80, had one or more lifetime substance dependence symptom (excluding ND symptoms) and had at least one conduct disorder symptom. The GADD is a longitudinal study currently in the second wave of data collection. Data from wave 1 were included in the analysis. Psychiatric diagnoses were evaluated using the DIS or Diagnostic Interview Schedule for Children (DISC; Shaffer et al. 2000) for those under 17 years of age. At wave 1, 23% of the sample met the criteria for lifetime major depression, 11% for generalized anxiety and 57% for antisocial personality disorder
