The dataset comprises gene expression data from brain tissues that were posthumously collected from more than 600 individuals with AD diagnosis, HD diagnosis, or with normal non-demented brains. All brains were obtained from individuals for whom both the donor and the next of kin had completed the Harvard Brain Tissue Resource Center Informed Consent (form available at: http://www.brainbank.mclean.org/PDF files/Consent.pdf). All tissue and research were conducted according to the Harvard Brain Tissue Resource Center Guidelines (including: HUMAN TISSUE HANDLING RISKS & SAFETY PRECAUTIONS agreement; HUMAN TISSUE SINGLE USER agreement, and HBTRC ACKNOWLEDGMENT agreement, available at http://www.brainbank.mclean.org/PDF files/TissueRequest.PDF). The study was approved by McLean Hospital Institutional Review Board.
