Due to known sex-disparities in the presentation of depression, incidence rate, and the suggestion of differences in underlying biology, we tested for sex-specific effects on our top SNPs as well as genotype-sex interaction for each SNP in the 23andMe discovery cohort (Supplementary Table 8). In the discovery cohort, four SNPs had nominal P<0.05 but none survived a multiple testing correction. No results reached nominal P<0.05 in the replication cohort. Our GWAS results thus provide no support for gender differences in genetic predisposition to depression.
