The independent effect of each GRS SNP on this set of related phenotypes is presented in Supplementary Table 7. Importantly, while rs12552 in the OLFM4 region was not strongly supported in the replication dataset, this SNP is associated with increased reporting of panic attacks, use of medication to treat mental health problems, prescription sleep aids, and pain medication, BMI greater than 27, earlier age-of-onset of MDD, and commensurately associated with lower continuous age of onset. Individually, rs12552 and rs4543289 had the largest effect on age-at-onset, with a total of five SNPs having nominal significance (p-val < 0.05).
