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Chunk #2 — Introduction

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Genome-wide association studies establish that human intelligence is highly heritable and polygenic.
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We present here the results of a genome-wide association study (GWAS) which examines cognitive ability phenotype-genotype associations in the five cohorts which constitute the CAGES (Cognitive Ageing Genetics in England and Scotland) project: the Lothian Birth Cohorts of 1921 and 1936 (LBC1921, LBC1936), the Aberdeen Birth Cohort 1936 (ABC1936), and the Manchester and Newcastle Longitudinal Studies of Cognitive Aging (Supplementary Table 1). All five cohorts comprise non-clinical samples of relatively healthy people from middle to older adulthood with detailed, though not identical, cognitive phenotypes.