The down-sampled MOOD (cases = 95,481, controls = 287,932, non-overlapping N = 280,214) showed increased similarity to PGC BD compared to MOOD, but remained more similar to PGC MDD. Nineteen loci reached genome-wide significance in down-sampled MOOD, including nine (20%) from PGC MDD, compared with two (11%) reported in PGC BD (Supplementary Table 3). 17/19 loci were also observed in MOOD. Of the two loci not observed in MOOD, one passed genome-wide significance in PGC BD.
