We meta-analysed the PGC MDD, PGC BD and the UKB MDD cohorts (MOOD, cases = 185,285, controls = 439,741, non-overlapping N = 609,424). 73 loci reached genome-wide significance, of which 55 were also seen in the meta-analysis of PGC MDD and UKB MDD (combined MDD, Supplementary Table 3, Supplementary Figures 1 and 2). Results are summarised in Table 1: 39 of the 44 PGC MDD loci reached genome-wide significance in MOOD (Supplementary Table 3, Supplementary Figures 1–8). In comparison, only four of the 19 PGC BD loci reached genome-wide significance in MOOD. MOOD loci overlapped considerably with previous studies of depression and depressive symptoms (51/73) (20, 23, 48–52), bipolar disorder (3/73) (53–56), neuroticism (32/73) (23, 57–59), and schizophrenia (15/73) (32, 60), although participants overlap between MOOD and many of these studies. Locus 52 (chromosome 12) passed genome-wide significance in a previous meta-analysis of broad depression and bipolar disorder, although the two other loci from this study did not replicate (51). Six of the 73 associations are entirely novel (p > 5×10−8 in previous studies of all phenotypes; Table 1, Supplementary Table 4).
