Meta-analysis results were assessed for genome-wide inflation of test statistics using LDSC (25). The LDSC intercept was significantly >1 in most cases (1.00–1.06), which has previously been interpreted as confounding (Supplementary Table 2). However, such inflation can occur in large cohorts without confounding (47). Estimates of inflation not due to polygenicity were small in all meta-analyses (4–7%, Supplementary Table 2).
