Additional analyses were performed to identify shared and distinct mood disorder loci, using mtCOJO, an extension of GSMR (Supplementary Methods) (41, 42). Analyses were performed on combined MDD conditional on PGC BD, and on PGC BD conditional on combined MDD (Supplementary Results). To identify loci with opposite directions of effect between combined MDD and PGC BD, the MOOD meta-analysis was repeated with reversed direction of effects for PGC BD (Supplementary Methods and Results).
