In another study, Itti compared brain volumes and measures of cognitive functioning between a group of 18, XXY adult males (18 to 63 years of age) and 20 controls matched on age and handedness [Itti, 2006]. The XXY males in this study were not identified prospectively, but were identified from a clinic for hypogonadism rather than for having any specific behavioral or cognitive abnormalities. Volumes of total brain volume, cerebellar volume, gray matter lobar volumes, and the hippocampus were drawn manually. Findings included decreased volume in the left temporal lobe and increased volume of the lateral ventricles. Results were not different between the subgroup of 47,XXY who had received testosterone supplementation versus those who had not.
