The mRNA modules significantly associated with AD case-status were assessed for enrichment of brain cell-type specific co-expression genes using the ‘UserListEnrichment’ option in WGCNA, which allows for detection of statistical enrichment of external a priori gene sets associated with several phenotypes and tissues. Statistical significance of enrichment of genes from cell-type specific gene sets within our mRNA co-expression modules was assessed by one tail hypergeometric test (adj. p≤ 0.05) [94].
