Chunk #51 — Methods and Materials — Gene set enrichment analysis

Source

Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence.

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Gene set enrichment analysis (GSEA) was used for detection of known biological processes and pathways enriched within the mRNA modules using GSEA v2.0.14 software from the Broad Institute, as previously described [95, 96]. Individual gene lists for each of the mRNA modules significantly correlated with AD case-status were generated by rank-ordering all differentially expressed mRNA transcripts by their module membership (MM) to each of the AD-associated modules.