Chunk #22 — 3. CENTRAL GLUTAMATE ACTIVITY AND ALCOHOL DEPENDENCE — 3.2 Metabotropic Glutamate Receptors and Alcohol

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Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.

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It has been shown that ethanol-binge drinking by mice upregulates mGlu1/ 5-Homer2 signaling in several mesocorticolimbic structures including the Acb83,84 and the central amygdala (CeA)85 and activation of either or both of these Group I mGluRs is required for mice to manifest binge-drinking behavior.83–85