The expression of 5218 transcripts in the hippocampus was significantly correlated with that of Cd14 (p < 0.05) in the Affymetrix dataset. However, only 524 known transcripts were left after filtering by genetic, partial, and literature correlations (S1A Table). Among these genes, 79 (or about 15% of 524 genes) had significant expression changes after ethanol treatment (S1B Table). These two sets of genes, the collection of 524 genes and the ethanol treated gene set of 79 genes, were submitted for gene ontology analysis to identify those categories with over-represented biological and molecular functions. For the whole set of genes, significant categories for biological processes included: “immune system process” (126 genes, adjP≤2.58e-48), “cell death” (106 genes, adjP≤1.95e-28), “response to chemical stimulus (136 genes, adjP≤3.62e-35), and “response to stress” (136 genes, adjP≤5.38e-34). The significant categories for molecular function were: “cytokine binding” (9 genes, adjP≤6.22e-05) and “cytokine receptor binding” (20 genes, adjP≤2.59e-07). For the gene set with significant expression change after ethanol-treatment, significant categories for biological processes included: “immune system processes” (20 genes, adjP≤-2.97e-07), “response to chemical stimulus” (26 genes, adjP≤5.49e-08), and “inflammatory
