We used TWAS FUSION20 to perform a TWAS of OCD. We used brain gene expression weights from the PsychENCODE103 and linkage disequilibrium information from the 1000 Genomes Project Phase 3 (ref. 95). TWAS FUSION uses reference linkage disequilibrium and reference gene expression panels with GWAS summary statistics to estimate the association between gene expression and OCD risk. These data were processed with the test statistics from the OCD GWAS to estimate the expression–GWAS association statistic. We corrected for multiple testing using Bonferroni correction.
