paperKB
coga / coga-kb
Help
Sign in

Chunk #7 — RESULTS — Transcriptome-wide association analysis.

Source
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.
Embedded
yes

Text

the 76 prioritized risk genes. The B4GALT2-205 isoform located in the genome-wide significant locus on chromosome 1 showed the strongest association (P = 7 × 10−11), with lower predicted expression in ADHD compared to controls (Supplementary Fig. 7a). The expression model for B4GALT2-205 implicated four genome-wide significant variants. The second top gene was PPP1R16A (P = 1.4 × 10−8), which showed a predicted under-expression in cases compared to controls. The expression model for this gene implicated one genome-wide significant variant (Supplementary Fig. 7b).