Gene-based association analysis using MAGMA27 identified 45 exome-wide significant genes (P < 2.72 × 10−6 (0.05/18,381 genes)) associated with ADHD (Supplementary Table 13). Gene association results across the entire genome were tested for a relationship with tissue-specific gene expression. This showed that brain-expressed genes, and in particular genes expressed in the cortex, are associated with ADHD (Supplementary Fig. 8). This result was supported by LDSC-SEG30 analysis, showing a significant enrichment in the heritability by variants located in genes specifically expressed in the frontal cortex (Supplementary Table 14).
