Unfortunately, this docs not appear to be the case. Mania and depression are also very frequent in many WM diseases60 This illustrates once again the spectrum ranging from bipolar disorder to schizophrenia. However, against such a proposal, it is worth mentioning that late-onset ALD and MLD seem to have some specificity for psychosis. We were not able to find any reports of mania or depression in ALD or MLD through our reading or through Medline searches.
