Whole-genome SNP-heritability was estimated with GCTA in the CADD sample. SNPs genotyped in the current study explained 27.8% of the CADD sample variance in BD (SE=0.15, p=0.03). The point estimate of heritability remained fairly stable when the sample was restricted to individuals estimated to be <2.5% identical-by-state (N=1148, V(G)/Vp=30.9%, SE=0.28, p=0.10) or those individuals with only Caucasian ancestry (as determined by an examination of ancestry component plots, N=1031, V(G)/Vp=49.3%, SE=0.31, p=0.06).
