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Chunk #49 — Discussion — Genetic Correlations with External GWAS

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A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency.
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socioeconomic status (Mallard et al. 2022b). These previous results suggest that adult alcohol use frequency measures may index a variety of socioeconomic and environmental constructs that are not of immediate relevance in describing the etiology of clinically relevant alcohol use behaviors (Kranzler et al. 2022; Mallard et al. 2022b). In the current study, adult alcohol use frequency demonstrated nominally a negative genetic correlation with cigarettes per day and a nominally positive genetic correlation with educational attainment. Though these results were not statistically significant, these point estimates align with previous work (Kranzler et al. 2022; Mallard et al. 2022b) to suggest that adult alcohol use frequency is dissimilar from other adult alcohol use behaviors that demonstrate association with externalizing outcomes.