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Chunk #17 — Methods

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Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics.
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To assess the impact of down-sampling on the factor loadings and model fit, we suggest forcing the best-fitting factor solution from the Genomic SEM analysis of the full dataset (that includes restricted data) onto the empirical genetic covariance matrix of the down-sampled summary statistics, and then evaluating the stability of the factor loadings and factor model fit indicators (e.g., the comparative fit index or the root mean square residual). We do not suggest searching for a better factor solution with the down-sampled indicators because the aim is to evaluate whether down-sampled analyses are representative of their corresponding versions with restricted data.