Thus, we ran the best-fitting Genomic SEM factor model of the original study (Karlsson Linnér et al. 2021): a single-factor model with seven indicator phenotypes (ADHD, ALCP, CANN, FSEX, NSEX, RISK, and SMOK), using unit variance identification of the factor model without SNP effects. However, in the analysis reported here, the input summary statistics for SMOK and CANN were replaced by down-sampled versions (see Step 1). We refer to the original factor model based on analyses with 23andMe data as the EXT factor and the down-sampled version as the EXT-minus-23andMe factor.3.What is the loss of genetic signal at the factor level of down-sampled multivariate GWAS when the indicator phenotypes are down-sampled univariate GWASs?
