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Chunk #41 — Methods — Assessment of Statistical Significance via Block Jackknife

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An atlas of genetic correlations across human diseases and traits.
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For the two-step estimator, if we were to estimate the intercept in the first step, then obtain a jackknife standard error for the second step treating the intercept as fixed, the standard error would be biased downwards, because it would not take into account the uncertainty in the intercept. Instead, we jackknife both steps of the procedure, which appropriately accounts for uncertainty in the intercept and yields a valid standard error.