In order to demonstrate deficits in inhibitory processing in alcoholics, the Go-NoGo paradigm has been used in several studies. In a visual Go-NoGo task, Kamarajan et al. (2005) reported that controls manifested two bilateral sources, while alcoholics exhibited only a midline source during the Go condition that had a button press response. During the NoGo condition which involved inhibitory processing (and no button press), controls showed a stronger and focused source over the central region, while the alcoholics showed a weaker and diffuse source over the central and posterior regions (see Fig. 2). The CSD maps were statistically compared between controls and alcoholics using a randomization technique described in Srebro (1996), and found significant group differences in several brain regions.
