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Chunk #57 — Discussion

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Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.
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Given that the function of the product of this gene is currently unknown, determining this is now a priority in understanding how this genetic association translates into pathophysiology. The identification of its binding partners, be they DNA, RNA or protein, will offer the opportunity to identify a set of further candidate genes, each of which will benefit from down-stream genetic analysis based upon a much higher prior probability than typical candidate genes for schizophrenia.