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Chunk #56 — Discussion

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Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.
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However, given the absence of association with better function in controls, rather than being associated with cognitive ability, ZNF804A may be associated with a subtype of schizophrenia in which cognition is relatively spared. This hypothesis is in keeping with association between this locus not just to schizophrenia but also to bipolar disorder (31). To what extent, if at all, the results from the study of Walters and colleagues reflect the observations of altered connectivity in the earlier study (30) is unclear.