For AUDIT-C, when associations for the seven LD-pruned GWS SNPs on chromosome 4q23–q24 in EAs are conditioned on rs1229984, the most significant functional SNP in the region in that population, the only independent signal (using a Bonferroni-corrected p value < 0.05) is for rs1229978, near ADH1C (Supplementary Data 5). For AUD, when associations for the four LD-pruned GWS SNPs in EAs are conditioned on rs1229984, the only independent signal in that region is for rs1154433 near ADH1C. In the trans-population meta-analysis, rs5860563 is independent when conditioned on rs1229984 in EAs, and on rs2066702 in AAs, the most significant functional SNP in the region in AAs (Supplementary Data 6).
