To date, there remains a dearth of studies using an unbiased approach to examine the molecular underpinnings of OCD and related disorders, likely due to the difficulty of obtaining high quality post-mortem tissue samples. In the first transcriptomic study of OCD tissue, Jaffe and colleagues56 used a microarray approach to examine DEG in the dlPFC as a function of several disorders typified by obsessive thoughts and compulsive behaviors (eating disorders, OCD, OCPD, and tic disorder). The authors found 286 DEG when comparing OCD/OCPD/tic cases to controls. Interestingly, out of the 904 global DEG in our study, only 13 were identified as differentially expressed by Jaffe et al.56. While this is consistent with statistical challenges owing to the relatively small sample size for both studies (see57), it could also indicate that molecular dysregulation in the dlPFC could be distinct from what is seen in the adjacent OFC, as well as the striatum. This is especially interesting in light of neuroimaging findings that suggest hyperactivity at rest in the OFC24,25,58,59, while no such evidence exists for the dlPFC (though lateral OFC and
